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Reversing wrinkles? A “unprecedented” new study found a way.



Through science, we’ve gotten pretty good at slowing down the signs of aging. But what about actually reversing wrinkles? That’s a tall order. Or is it?

Researchers at the University of Alabama at Birmingham (USA) found a way to reverse wrinkles and hair loss by restoring mitochondrial function. The team published the findings in Cell Death & Disease


Mitochondria produce adenosine triphosphate (ATP), the “fuel" that supports healthy cell functioning. As we age and less ATP is produced, mitochondria start to function improperly. This causes visible signs of aging and age-related chronic diseases to develop.

Led by Keshav Singh, professor of genetics at the University of Alabama at Birmingham School of Medicine, the team found a way to reverse a DNA mutation that leads to mitochondrial dysfunction.

Great news, right? Well, so far scientists have only been able to produce these effects in mice, so it’s a little early to throw out your undereye cream. The findings are certainly promising, as Newsweek magazine reported:


The scientists activated a mutation in the mice that caused their mitochondrial function to decline, just like it does in humans when they age. In just four weeks, the mice started losing hair, showing gray hair and became lethargic. Between four and eight weeks, the mice developed wrinkled skin….

When the scientists turned off the mutation, the wrinkled skin and hair loss reversed. The mice returned back to their original appearance and mitochondrial function returned.


Interestingly, the team noted that mice and humans age quite similarly. Outer layers of the skin thicken, skin cell count increases, inflammation is present and hair loss occurs.

In discussing the reversal of the age-related signs, Professor Singh said, “To our knowledge, this observation is unprecedented.”