Yes, salmon sperm. Yes, injected. And yes—it works.

Lately, more people have been asking about salmon sperm injections—perhaps because they’ve gained popularity in the West, thanks to celebrities like the Kardashians and Jennifer Aniston. It sounds strange, but this skincare trend is actually backed by science and has been a staple in Asia for over a decade.

So what exactly are salmon sperm injections? Are they safe? Do they work? Here’s what you need to know.

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What Are Salmon Sperm Injections?

Also known as polynucleotides (PN) or PDRN, these treatments are derived from purified DNA extracted from salmon or trout sperm. This DNA closely resembles human DNA, making it highly compatible with our skin.

“It’s not actual sperm,” explains Dr Yeoh. “It’s the purified DNA extracted from salmon sperm, which is then processed to hydrate, repair and rejuvenate the skin from within.”

Think of it as a DNA injection—to boost and strengthen the skin’s health and resilience.

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Why Salmon DNA?

Salmon-derived DNA has been used in medical healing for over 20 years — originally for treating diabetic ulcers, surgical wounds and joint injuries.

In aesthetics, it’s known for its ability to:

• Boost collagen production
• Improve blood circulation and oxygen delivery
• Reduce inflammation
• Repair and regenerate skin
   

Salmon-derived PDRN is recognised for its biocompatibility with human skin.

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Why It’s Known as the Glass Skin Treatment

These injections give the skin a smooth, clear, luminous appearance — hence the nickname glass skin.

With regular treatments, the skin becomes hydrated, firm, radiant, and resilient, with a reinforced skin barrier.

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How We Use Polynucleotides at IYAC

At IYAC, we’ve worked with polynucleotides for over a decade, incorporating them into our routine treatments to support skin barrier function, especially in stressed or sensitive skin.

A. In the Clinic

We offer two ways to deliver polynucleotides in the clinic:

1. Injectables (Glass Skin Program)
Designed to enhance the penetration of PDRN into the skin’s surface layers. Numbing cream is applied beforehand, and an injector gun similar to microneedling is used for a comfortable and even delivery.

Minimal downtime: mild redness usually resolves within a day or two.

Used for:

• Repairing weakened skin barriers
• Treating acne-prone, scarred, or sensitive skin
• Supporting post-laser and eczema recovery
• Enhancing overall skin hydration and radiance
   

  2. Lasers (Needle-Free Option)
  Our Thulium Laser (1927nm, for Melasma and Healing ) combines thulium laser energy with salmon-derived PDRN to deliver a quick burst of hydration and healing.
  It soothes sensitive or inflamed skin, strengthens the skin barrier, and is useful for treating melasma and post-procedure recovery.

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B. For Hair and Scalp

Hair Growth (Microneedling with Polynucleotides)

As part of our Hair Growth Program, we use hair microneedling treatments to deliver a blend of salmon DNA, copper peptides and growth factors into the hair roots.
This helps to improve scalp health and encourages hair to grow thick and strong.

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How Salmon Sperm Injections Are Done

• Treatments are straightforward and comfortable.
• For injectables, numbing cream ensures tolerable discomfort, with mild redness for 1–2 days.
• For needle-free options, electroporation allows deep serum absorption with no pain or downtime.
   

Polynucleotides are superficial injections (skinboosters), highly fluid, and unlike dermal fillers, are not associated with vascular risks.

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Not Into Salmon? Here’s a Plant-Based Alternative

If you’re vegetarian or prefer a non-marine option, we offer PDLLA (Poly-D-L-Lactic Acid) — a plant-derived treatment made from fermented corn, which stimulates collagen renewal and helps address wrinkles, pores and scarring.

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In Summary

Salmon DNA treatments may have an unusual nickname, but they’re backed by real science and reliable results.
Our signature Glass Skin Program provides a targeted approach to experiencing these benefits, with minimal discomfort and downtime, for naturally beautiful results.

If you’re ready to explore scientifically-backed options that support skin clarity and resilience, we’re here to guide you every step of the way.